Inhibition of alkaline phosphatase by oestradiol phosphates

Inhibition of alkaline phosphatase by oestradiol phosphates.

specific biological activity when isolated from different species may differ chemically. The haemo. globins are an example of this (Porter & Sanger, 1948), and it is clear that some variation in structure may occur in such a series of compounds without the specific action being greatly modified. From solubility studies, Desreux & Herriott (1939) postulated the existence of at least two componen...

Alkaline phosphatase revisited: hydrolysis of alkyl phosphates.

Escherichia coli alkaline phosphatase (AP) is the prototypical two metal ion catalyst with two divalent zinc ions bound approximately 4 A apart in the active site. Studies spanning half a century have elucidated many structural and mechanistic features of this enzyme, rendering it an attractive model for investigating the potent catalytic power of bimetallic centers. Unfortunately, fundamental ...

The inhibition of alkaline phosphatase by beryllium.

Recent clinical reports of pulmonary disease occurring in workers in the beryllium industry have stimulated new interest in the biochemical action of this element (for a complete bibliography, see (1)). Although it has not been possible to produce in animals pathological conditions identical with those Eeen in beryllium workers, experimental administration of beryllium and its compounds has res...

Self-cleavable bioluminogenic luciferin phosphates as alkaline phosphatase reporters.

Running title: Alkaline phosphatase inhibition and Francisella survival 1 Francisella DnaK Inhibits Tissue Nonspecific Alkaline Phosphatase

Following pulmonary infection with Francisella tularensis, we observed an unexpected but significant reduction of alkaline phosphatase, an enzyme normally up-regulated following inflammation. However, no reduction was observed in mice infected with a closely related Gram negative pneumonic organism (Klebsiella pneumonia) suggesting the inhibition may be Francisella specific. In similar fashion ...